Palladium-Catalyzed intramolecular C-H Activation/C-C Bond Formation: A Straightforward Synthesis of Phenanthridines

被引：81

作者：

Peng, Jinsong ^{[1
,2
]}

Chen, Tonghui ^{[1
]}

Chen, Chunxia ^{[1
]}

Li, Bin ^{[1
,2
]}

机构：

[1] NE Forestry Univ, Dept Chem & Chem Engn, Coll Sci, Harbin 150040, Peoples R China

[2] NE Forestry Univ, Postdoctoral Mobile Res Stn Forestry Engn, Harbin 150040, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 76卷 / 22期

基金：

中国博士后科学基金;

关键词：

6-SUBSTITUTED PHENANTHRIDINES; MEDIATED SYNTHESIS; DIRECT ARYLATION; CONVENIENT SYNTHESIS; BENZYNE CYCLIZATION; DERIVATIVES; MECHANISM; ISOQUINOLINES; CONSTRUCTION; ACYLOXIMES;

D O I：

10.1021/jo2017108

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The palladium-catalyzed intramolecular C-H activation/C-C cross-coupling has been developed for a straightforward and efficient synthesis of phenanthridines. With Pd(OAc)(2) (4 mol %) as the catalyst, PCy3 (8 mol %) as the ligand, and Cs2CO3 as the base, this protocol was applied to synthesize a small library of phenanthridine derivatives in good yields in THF.

引用

页码：9507 / 9513

页数：7

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