Serum Prolactin, Preptin, CCL 18 and Genetic Polymorphisms in Iraqi Women with Polycystic Ovary Syndrome

The polycystic ovary syndrome is an endocrine condition. One of the leading causes of female infertility and the most common disorder among women. The work was carried out on 100 Iraqi women (50 cases confirmed with PCOS and 50 controls) between October 2019 and March 2020. Blood samples were collected from the Advanced Institute of Infertility Diagnosis and Assisted Reproductive Technology at AL-Nahrain University and a private laboratory. ELISA was used to evaluate the biochemical parameters of Preptin, and CCL 18, while FSH, insulin, and LH were measured by using AFIAS-6 in serum samples .The findings of this study indicate that, as opposed to the control group, values of prolactin (ng/ml), insulin (mu IU/m1), LH (mu IU/ml), Preptin (pg/ml) and CCL 18 (ng/ml) Quite higher in PCOS patients (P <0.001), while the control group showed highly significant value (P <0.05) in testosterone (ng/ml) and FSH (mIU/ml), finally PRLR gene expression levels in PCOS patients were significantly increased by 3.6 times. In summary, the levels of Preptin and CCL18 can be regarded as PCOS markers.