Cell-Penetrating Homochiral Cyclic Peptides as Nuclear-Targeting Molecular Transporters

被引：167

作者：

Mandal, Deendayal ^{[1
]}

Shirazi, Amir Nasrolahi ^{[1
]}

Parang, Keykavous ^{[1
]}

机构：

[1] Univ Rhode Isl, Dept Biomed & Pharmaceut Sci, Kingston, RI 02881 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 41期

基金：

美国国家科学基金会;

关键词：

amphiphiles; drug delivery; endocytosis; nuclear targeting; peptides; INTRACELLULAR DELIVERY; TAT PEPTIDE; DOMAIN; SH2; INTERNALIZATION; MECHANISM; ANALOGS;

D O I：

10.1002/anie.201102572

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Going round in circles: Amphipathic L-cyclic peptides facilitate the cellular uptake of fluorescently labeled lamivudine and a phosphopeptide. A corresponding fluorescently labeled conjugate F-[W 5R 4K] showed a highly efficient translocation in the nucleus of colon adenocarcinoma, breast carcinoma, and human ovarian adenocarcinoma (see picture). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9633 / 9637

页数：5

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