Increases in SLT2 expression and chitin content are associated with incomplete killing of Candida glabrata by caspofungin

被引：56
作者：
Cota, Jason M. [1 ,2 ]
Grabinski, Jodi L. [1 ,2 ]
Talbert, Robert L. [1 ,2 ]
Burgess, David S. [1 ,2 ]
Rogers, P. David [3 ]
Edlind, Thomas D. [4 ]
Wiederhold, Nathan P. [1 ,2 ]
机构：
[1] Univ Texas Austin, Coll Pharm, Austin, TX 78229 USA
[2] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA
[3] Univ Tennessee, Coll Pharm, Memphis, TN USA
[4] Drexel Univ, Coll Med, Philadelphia, PA 19104 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 03期
关键词：
D O I：
10.1128/AAC.01542-07
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Incomplete killing was observed for caspofungin against Candida glabrata, which was associated with increased SLT2 expression and elevated chitin content. In contrast, fungicidal activity and no chitin increase were observed in an isogenic Delta slt2 strain, suggesting a role for SLT2 and chitin production in the response of C. glabrata to caspofungin.
引用
收藏
页码：1144 / 1146
页数：3
相关论文
共 25 条
  • [1] 14-3-3 connects glycogen synthase kinase-3β to tau within a brain microtubule-associated tau phosphorylation complex
    Agarwal-Mawal, A
    Qureshi, HY
    Cafferty, PW
    Yuan, ZF
    Han, D
    Lin, RT
    Paudet, HK
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (15) : 12722 - 12728
  • [2] Comparison of the fungicidal activities of caspofungin and amphotericin B against Candida glabrata
    Barchiesi, F
    Spreghini, E
    Tomassetti, S
    Arzeni, D
    Giannini, D
    Scalise, G
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (12) : 4989 - 4992
  • [3] Caspofungin in combination with amphotericin B against Candida glabrata
    Barchiesi, F
    Spreghini, E
    Fothergill, AW
    Arzeni, D
    Greganti, G
    Giannini, D
    Rinaldi, MG
    Scalise, G
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (06) : 2546 - 2549
  • [4] Paradoxical effect of echinocandins across Candida species in vitro:: Evidence for echinocandin-specific and Candida species-related differences
    Chamilos, Georgios
    Lewis, Russell E.
    Albert, Nathaniel
    Kontoyiannis, Dimitrios P.
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (06) : 2257 - 2259
  • [5] Characterizing the effects of caspofungin on Candida albicans, Candida parapsilosis, and Candida glabrata isolates by simultaneous time-kill and postantifungal-effect experiments
    Clancy, Cornelius J.
    Huang, Hong
    Cheng, Shaoji
    Derendorf, Hartmut
    Nguyen, M. Hong
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (07) : 2569 - 2572
  • [6] In vitro pharmacodynamics of anidulafungin and caspofungin against Candida glabrata isolates, including strains with decreased caspofungin susceptibility
    Cota, Jason
    Carden, Michael
    Graybill, John R.
    Najvar, Laura K.
    Burgess, David S.
    Wiederhold, Nathan P.
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (11) : 3926 - 3928
  • [7] Promoter-dependent disruption of genes: simple, rapid, and specific PCR-based method with application to three different yeast
    Edlind, TD
    Henry, KW
    Vermitsky, JP
    Edlind, MP
    Raj, S
    Katiyar, SK
    [J]. CURRENT GENETICS, 2005, 48 (02) : 117 - 125
  • [8] The protein kinase C-mediated MAP kinase pathway involved in the maintenance of cellular integrity in Saccharomyces cerevisiae
    Heinisch, JJ
    Lorberg, A
    Schmitz, HP
    Jacoby, JJ
    [J]. MOLECULAR MICROBIOLOGY, 1999, 32 (04) : 671 - 680
  • [9] Influence of test conditions on antifungal time-kill curve results: Proposal for standardized methods
    Klepser, ME
    Ernst, EJ
    Lewis, RE
    Ernst, ME
    Pfaller, MA
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (05) : 1207 - 1212
  • [10] Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method
    Livak, KJ
    Schmittgen, TD
    [J]. METHODS, 2001, 25 (04) : 402 - 408
123