VALIDATION THIN LAYER CHROMATOGRAPHY FOR THE DETERMINATION OF NAPROXEN IN TABLETS AND COMPARISON WITH A PHARMACOPEIL METHOD

被引：23

作者：

Pyka, Alina ^{[1
]}

Wiatr, Ewa ^{[1
]}

Kwiska, Karolina ^{[1
]}

Gurak, Danuta ^{[1
]}

机构：

[1] Med Univ Silesia, Dept Analyt Chem, Fac Pharm, PL-41200 Sosnowiec, Poland

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | 2011年 / 34卷 / 10-11期

关键词：

densitometry; naproxen; pharmaceutical analysis; quantitative analysis; spectrodensitometry; spectrophotometry; TLC; IBUPROFEN;

D O I：

10.1080/10826076.2011.571152

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Adsorption thin layer chromatography with densitometry has been established for the identification and the quantification of naproxen in tablets. UV densitometry was performed in absorbance mode at 230nm. The presented method was validated by specificity, range, linearity, accuracy, precision, detection limit, quantitative limit, and robustness. The TLC-densitometric method was also compared with a pharmacopeial UV-spectrophotometric method for the assay of naproxen, and the results confirmed statistically that the TLC-densitometric method can be used as a substitute method.

引用

页码：829 / 847

页数：19

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