Anti-inflammatory response of mannose-conjugated polyrotaxane endocytosed into macrophage

被引：2

作者：

Ehashi, Tomo ^{[1
]}

Hyun, Hoon ^{[1
]}

Yui, Nobuhiko ^{[1
,2
]}

机构：

[1] Japan Adv Inst Sci & Technol, Sch Mat Sci, Nomi, Ishikawa 9231292, Japan

[2] CREST, JST, Chiyoda Ku, Tokyo 1020075, Japan

来源：

MACROMOLECULAR RESEARCH | 2011年 / 19卷 / 05期

关键词：

mannose-conjugated polyrotaxane; endocytosis; macrophage response; SURFACE-CHEMISTRY; IN-VIVO; J774; MACROPHAGES; EXPRESSION; RECEPTOR; BIOMATERIALS; PHAGOCYTOSIS; IMPLANTATION; POLYMERS; MOBILITY;

D O I：

10.1007/s13233-011-0506-8

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Macrophage response to mannose-conjugated polyrotaxane (Man-PRX) was examined in terms of the morphological changes in macrophage-like J774.1 cells and their inflammation-related cytokine expression. The results obtained were compared with those by mannose-conjugated alpha-CD (Man-CD), mannan, and mannose-conjugated polyacrylamide (Man-PAAm). The largest percentage of the morphological change was observed for Man-PRX, which is presumably induced by mannose receptor-mediated endocytosis. In the cytokine expression experiments, anti-inflammatory cytokine was expressed by Man-PRX but the pro-inflammatory cytokine level was increased by Man-PAAm. Therefore, Man-PRX has great potential as anti-inflammatory biomaterial.

引用

页码：495 / 500

页数：6

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