Establishment of an immortalized human endometrial stromal cell line with functional responses to ovarian stimuli

被引：25

作者：

Yuhki, Munehiro ^{[1
]}

Kajitani, Takashi ^{[2
]}

Mizuno, Takakazu ^{[1
]}

Aoki, Yuko ^{[1
]}

Maruyama, Tetsuo ^{[2
]}

机构：

[1] Chugai Pharmaceut Co Ltd, Kamakura Res Labs, Kanagawa 2478530, Japan

[2] Keio Univ, Sch Med, Dept Obstet & Gynecol, Tokyo 1608582, Japan

来源：

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY | 2011年 / 9卷

关键词：

TUMOR-NECROSIS-FACTOR; PROGESTERONE-RECEPTOR; PERITONEAL-FLUID; MENSTRUAL-CYCLE; TNF-ALPHA; EXPRESSION; DECIDUALIZATION; INTERLEUKIN-1-BETA; ESTRADIOL; HORMONE;

D O I：

10.1186/1477-7827-9-104

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Studies on the mechanisms of decidualization and endometriosis are often hampered by lack of primary endometrial cells. To facilitate in vitro studies, we established a human endometrial stromal cell line, KC02-44D, immortalized with human telomerase reverse transcriptase. Upon exposure to ovarian stimuli, KC02-44D cells showed similar cytoskeletal marker or gene expression and biochemical phenotype to primary endometrial stromal cells. KC02-44D would be useful for studies of human endometrial function and its associated pathologies.

引用

页数：9

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