Fused cyanopyrimidines .2. Synthesis and reactions of fused cyanopyrimidine derivatives as affecting enzymatic agents

被引：27

作者：

AbdelAziz, SA ^{[1
]}

Allimony, HA ^{[1
]}

ElShaaer, HM ^{[1
]}

Ali, UF ^{[1
]}

AbdelRahman, RM ^{[1
]}

机构：

[1] AIN SHAMS UNIV,FAC EDUC,DEPT BIOL & GEOL SCI,CAIRO,EGYPT

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1996年 / 113卷 / 1-4期

关键词：

fused-cyanopyrimidine; heterobicyclic systems; NMR spectra; UV spectra; IR spectra; biological activity;

D O I：

10.1080/10426509608046379

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Some new fused heterobicyclic systems, such as thiazolo[3, 2-a]-pyrimidin-5-one (3), 2, 3-tetrahydrothiazolo[3, 2-a]pyrimidin-5-one (5), 2, 4-tetrahydrothiazino[3, 2-a]pyrimidin-3 (6), 3-dihydrothiazino[3, 2-a]pyrimidin-2, 4, 6-trione (7), 3-arylidenethiazino[3, 2-a]pyrimidin-2, 4, (8) and/or the related nitrogen compounds, such as 2, 3-tetrahydroimidazolo[3, 2-a]-pyrimidin-5-one (9), 1-aryl-2, 3-tetrahydroimidazolo[3, 2-a]pyrimidin-5-one (11), quinazolino[3, 2-a]pyrimidin-6, 8-dione (12) and 3-mercapto-1, 2, 4-triazolo[4, 3-a]pyrimidin-5-one (14) have been synthesized by the interaction of 2-mercapto-4-arylidene-5-cyanopyrimidin-6(1H)one (1) with alpha, beta-bifunctional nitrogen, oxygen and/or sulfur compounds. The structures have been characterized by elemental analyses, IR, UV, H-1 NMR and mass spectral data. Some newly prepared compounds revealed a moderate effect on the activity of cellobiase produced by Aspergillus nidulans.

引用

页码：67 / 77

页数：11

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