Palladium catalyzed alkylation of indole via aliphatic C-H bond activation of tertiary amine

被引：36

作者：

Ramachandiran, K. ^{[1
]}

Muralidharan, D. ^{[1
]}

Perumal, P. T. ^{[1
]}

机构：

[1] Cent Leather Res Inst CSIR, Div Organ Chem, Madras 600020, Tamil Nadu, India

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 28期

关键词：

Palladium; C-H activation; 1,1-Bis-indolymethane; C-C coupling; Alkylation of indole; DIRECT ARYLATION; NITROGEN ATOM; DIRECT FUNCTIONALIZATION; MECHANISTIC ASPECTS; EFFICIENT SYNTHESIS; COPPER; DERIVATIVES; COMPLEXES; ALDEHYDES; ALKENYLATION;

D O I：

10.1016/j.tetlet.2011.04.110

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alkylation of indoles has been achieved via Pd-catalyzed aliphatic C-H bond activation of tertiary amine coupling with indole followed by C-N bond cleavage and subsequent addition of indole. This method involves the migration of alkane chain from tertiary amine to indole. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：3579 / 3583

页数：5

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