Gastrointestinal Dopamine in Inflammatory Bowel Diseases: A Systematic Review

被引：16

作者：

Kurnik-Lucka, Magdalena ^{[1
]}

Pasieka, Pawel ^{[1
]}

Laczak, Patrycja ^{[1
]}

Wojnarski, Marcin ^{[1
]}

Jurczyk, Michal ^{[1
]}

Gil, Krzysztof ^{[1
]}

机构：

[1] Jagiellonian Univ Med Coll, Dept Pathophysiol, Fac Med, PL-31121 Krakow, Poland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 23期

基金：

英国科研创新办公室;

关键词：

dopamine; dopamine receptors; inflammatory bowel disease; CD; UC; gastrointestinal; gut; animal models; Parkinson's disease; INDUCED GASTRIC-ULCERS; HIGH-SALT DIET; CROHNS-DISEASE; EXPERIMENTAL COLITIS; ULCERATIVE-COLITIS; NERVOUS-SYSTEM; T-CELLS; CHEMICAL SYMPATHECTOMY; GUT MICROBIOTA; MOUSE MODELS;

D O I：

10.3390/ijms222312932

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: an increased prevalence of gastro-duodenal ulceration was described almost sixty years ago as prodromal to idiopathic Parkinson's disease, while duodenal ulcers have been rarely diagnosed in patients with schizophrenia. The cytoprotective role of dopamine in animal models of gastrointestinal ulcerations has also been described. Interestingly, Parkinson's disease (PD) might share common pathophysiological links with inflammatory bowel disease (IBD) as epidemiological and genetic links already suggest. Thus, the aim of our study was to review the existing literature on the role of the gastrointestinal dopaminergic system in IBD pathogenesis and progression. Methods: a systematic search was conducted according to the PRISMA methodology. Results: twenty-four studies satisfied the predetermined criteria and were included in our qualitative analysis. Due to different observations (cross-sectional studies) as well as experimental setups and applied methodologies (in vivo and in vitro studies) a meta-analysis could not be performed. No ongoing clinical trials with dopaminergic compounds in IBD patients were found. Conclusions: the impairment of the dopaminergic system seems to be a significant, yet underestimated, feature of IBD, and more in-depth observational studies are needed to further support the existing preclinical data.

引用

页数：30

共 102 条

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