The cAMP pathway and the control of adrenocortical development and growth

被引：48
作者：
de Joussineau, Cyrille [1 ]
Sahut-Barnola, Isabelle [1 ]
Levy, Isaac [2 ]
Saloustros, Emmanouil [2 ]
Val, Pierre [1 ]
Stratakis, Constantine A. [2 ]
Martinez, Antoine [1 ]
机构：
[1] Clermont Univ, CNRS, INSERM, UMR6247,U931, F-63171 Aubiere, France
[2] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Dev Endocrinol & Genet, Sect Endocrinol & Genet, NIH, Bethesda, MD USA
来源：
MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2012年 / 351卷 / 01期
关键词：
cAMP; PKA; Adrenal; Pathology; HUMAN ADRENAL-CORTEX; SUBUNIT TYPE 1A; KINASE-A PKA; CARNEY COMPLEX; REGULATORY SUBUNIT; BETA-CATENIN; X-ZONE; CYTOCHROME B5; GLUCOCORTICOID-RECEPTOR; MICRORNA SIGNATURE;
D O I：
10.1016/j.mce.2011.10.006
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In the last 10 years, extensive studies showed that the cAMP pathway is deregulated in patients suffering from adrenocortical tumours, and particularly in primary pigmented nodular adrenocortical disease (PPNAD). Here we describe how evidence arising from the analysis of patients' data, mouse models and in vitro experiments, have shed light on the cAMP pathway as a central player in adrenal physiopathology. We also show how novel data generated from mouse models may point to new targets for potential therapies. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：28 / 36
页数：9
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