Metabolic syndrome in adult cancer survivors: A meta-analysis

被引:34
作者
Jung, Hyun-Suk [1 ]
Myung, Seung-Kwon [2 ,3 ]
Kim, Byung-Su [4 ]
Seo, Hong Gwan [2 ,5 ]
机构
[1] Sungkyunkwan Univ, Sch Med, Total Healthcare Ctr, Kangbuk Samsung Hosp, Seoul, South Korea
[2] Natl Canc Ctr, Ctr Canc Prevent & Detect, Goyang, South Korea
[3] Natl Canc Ctr, Canc Epidemiol Branch, Res Inst, Goyang, South Korea
[4] Korea Ctr Dis Control & Prevent KCDC, Choongchung Buk Do, South Korea
[5] Natl Canc Control Inst, Goyang, South Korea
关键词
Metabolic syndrome; Cancer survivor; Meta-analysis; LONG-TERM SURVIVORS; ACUTE LYMPHOBLASTIC-LEUKEMIA; GROWTH-HORMONE DEFICIENCY; BODY-MASS INDEX; CHILDHOOD-CANCER; CARDIOVASCULAR-DISEASE; PREVALENCE; OBESITY; RISK; TRANSPLANTATION;
D O I
10.1016/j.diabres.2011.08.029
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Cross-sectional studies have reported inconsistent findings on whether the risk of metabolic syndrome is high among cancer survivors. We conducted a meta-analysis of cross-sectional studies. Methods: We searched MEDLINE (PubMed) and EMBASE in April 2010. Two evaluators independently reviewed and selected articles, based on pre-determined selection criteria. Results: Out of 257 articles meeting our initial criteria, 9 cross-sectional studies, which involved 6763 participants (1762 cases and 5001 controls) were included in the final analysis. Compared with the healthy control groups, the cancer survivors were at an increased risk of metabolic syndrome, in the random-effects meta-analysis of all 9 cross-sectional studies (OR = 1.84; 95% CI = 1.14-2.97; I-2 = 80.5). In the subgroup meta-analysis by cancer type, a significant positive association was observed for hematologic malignancies, including ALL (acute lymphoblastic leukemia), AML (acute myelogenous leukemia), NHL (non-Hodgkin's lymphoma), and CML (chronic myelogenous leukemia) (OR = 1.94; 95% CI = 1.06-3.55; I-2 = 68.1%), whereas no significant association was found for non-hematologic malignancies, including testicular tumor, prostate cancer, sarcoma, and epithelial ovarian cancer. Conclusions: Our meta-analyses of cross-sectional studies found that adult cancer survivors with hematologic malignancies were at an increased risk of metabolic syndrome. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:275 / 282
页数:8
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