Effects of Tea Polyphenols and their Polymers on MAPK Signaling Pathways in Cancer Research

被引：17
作者：
Li, W. [1 ,2 ]
Mei, X. [1 ,3 ]
Tu, Y. Y. [1 ,3 ]
机构：
[1] Zhejiang Univ, Dept Tea Sci, Hangzhou 310058, Zhejiang, Peoples R China
[2] Zhejiang Shuren Univ, Dept Tea Sci, Hangzhou 310015, Zhejiang, Peoples R China
[3] Zhejiang Univ, Key Lab Hort Plant Growth Dev & Biotechnol, Minist Agr, Hangzhou 310058, Zhejiang, Peoples R China
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2012年 / 12卷 / 02期
关键词：
Cancer; EGCG; kinases; MAPK; signaling pathways; tea polyphenols; TF3; ACTIVATED PROTEIN-KINASES; N-TERMINAL KINASE; GREEN TEA; BLACK TEA; (-)-EPIGALLOCATECHIN GALLATE; EPIGALLOCATECHIN GALLATE; P38; MAPK; PROSTATE-CANCER; LUNG-CANCER; CELL-GROWTH;
D O I：
10.2174/138955712798995011
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The biological activities and mechanisms of tea polyphenols and their polymerics have been attractive issues in cancer research. The inhibition of tea polyphenols on cancer cells decreased cell proliferation and increased apoptosis. Tremendous evidences have shown that tea polyphenols suppress tumor promotion by inhibiting enzyme activities and blocking signal transduction pathways. Specifically, the mitogen activated protein kinases (MAPK) pathways have been implicated as an important target molecular for cancer prevention and therapy. The purpose of this review is to discuss the relationship between tea polyphenols and MAPK signaling pathways in cancer.
引用
收藏
页码：120 / 126
页数：7
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