Expression of T cell-related lncRNAs in multiple sclerosis

被引：9

作者：

Dadyar, Maryam ^{[1
]}

Hussen, Bashdar Mahmud ^{[2
,3
]}

Eslami, Solat ^{[4
,5
]}

Taheri, Mohammad ^{[6
]}

Emadi, Farhad ^{[7
]}

Ghafouri-Fard, Soudeh ^{[1
]}

Sayad, Arezou ^{[1
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Sch Med, Dept Med Genet, Tehran, Iran

[2] Hawler Med Univ, Coll Pharm, Dept Pharmacognosy, Erbil, Kurdistan Regio, Iraq

[3] Lebanese French Univ, Ctr Res Strateg Studies, Erbil, Kurdistan Regio, Iraq

[4] Alborz Univ Med Sci, Sch Med, Dept Med Biotechnol, Karaj, Iran

[5] Alborz Univ Med Sci, Dietary Supplements & Probiot Res Ctr, Karaj, Iran

[6] Jena Univ Hosp, Inst Human Genet, Jena, Germany

[7] Shahid Beheshti Univ Med Sci, Skull Base Res Ctr, Tehran, Iran

来源：

FRONTIERS IN GENETICS | 2022年 / 13卷

关键词：

FLICR; NEST; RMRP; TH2-LCR; lncRNA; multiple sclerosis; T cell; FOXP3; EXPRESSION; SUSCEPTIBILITY; SUPPRESSION;

D O I：

10.3389/fgene.2022.967157

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Long non-coding RNAs (lncRNAs) have been demonstrated to in the pathophysiology of multiple sclerosis (MS). In order to appraise the role of T cell-related lncRNAs in this disorder, we assessed expressions of NEST, RMRP, TH2-LCR, MAFTRR and FLICR in MS patients and healthy individuals. We detected significant difference in the expression of RMRP and FLICR between cases and controls. There were substantial correlations between expressions of NEST, RMRP, TH2-LCR, MAFTRR and FLICR lncRNAs among patients, but not controls. The strongest correlations were found between RMRP and TH2-LCR, and between MAFTRR and RMRP with correlation coefficients of 0.69 and 0.59, respectively. ROC curve analysis revealed appropriate power of FLICR in differentiating between MS patients and healthy controls (AUC value = 0.84). Expression of NEST lncRNA was positively correlated with disease duration in MS patients, but negatively correlated with age at onset. In brief, we reported dysregulation of two T cell-related lncRNAs in MS patients and proposed FLICR as a putative marker for this disorder.

引用

页数：7

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