Solid-phase assisted N-1 functionalization of azamacrocycles

被引：14

作者：

Oliver, M

Jorgensen, MR

Miller, AD

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, Imperial Coll Genet Therapies Ctr, London SW7 2AZ, England

[2] IC Vec Ltd, London SW7 2AZ, England

来源：

SYNLETT | 2004年 / 03期

关键词：

solid-phase synthesis; azo-macrocycles; protecting groups; contrast agents;

D O I：

10.1055/s2004-815404

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple solid-phase assisted strategy for the N-1 functionalization of azamacrocycles is described. Compounds such as cyclen, cyclam and piperazine can be selectively modified by temporary attachment to solid-phase resins providing an efficient and clean method to prepare biomedically interesting moieteies.

引用

页码：453 / 456

页数：4

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