Polyphenols and Small Phenolic Acids as Cellular Metabolic Regulators

被引:13
作者
Obrenovich, Mark [1 ,2 ,3 ,4 ,5 ,6 ]
Li, Yi [7 ]
Tayahi, Moncef [3 ,8 ]
Reddy, V. Prakash [9 ]
机构
[1] Dept Vet Affairs Med Ctr, Res Serv, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Dept Chem, Cleveland, OH 44106 USA
[3] Gilgamesh Fdn Med Sci & Res, Cleveland, OH 44116 USA
[4] Univ Toledo, Dept Med & Biol Chem, Coll Pharm & Pharmaceut Sci, Toledo, OH 43614 USA
[5] Cleveland State Univ, Dept Chem, Cleveland, OH 44115 USA
[6] Cleveland State Univ, Biol & Environm Sci, Cleveland, OH 44115 USA
[7] St Louis Univ, Dept Nutr & Dietet, St Louis, MO 63103 USA
[8] Univ Cincinnati, Dept Elect & Comp Engn, CEAS Coll Engn, Cincinnati, OH 45221 USA
[9] Missouri Univ Sci & Technol, Dept Chem, Rolla, MO 65409 USA
关键词
polyphenols; microbiota; small phenolic acids; mass spectrometry; green tea; resveratrol; catechins; eugenol; whole genome sequencing; PLANT SECONDARY METABOLITES; CLOSTRIDIUM-DIFFICILE; IN-VITRO; EUGENOL; HEALTH; RESVERATROL; ANTIOXIDANT; MICROBIOTA; DISEASE; WINE;
D O I
10.3390/cimb44090285
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Polyphenols and representative small phenolic acids and molecules derived from larger constituents are dietary antioxidants from fruits, vegetables and largely other plant-based sources that have ability to scavenge free radicals. What is often neglected in polyphenol metabolism is bioavailability and the role of the gut microbiota (GMB), which has an essential role in health and disease and participates in co-metabolism with the host. The composition of the gut microbiota is in constant flux and is modified by multiple intrinsic and extrinsic factors, including antibiotics. Dietary or other factors are key modulators of the host gut milieu. In this review, we explore the role of polyphenols and select phenolic compounds as metabolic or intrinsic biochemistry regulators and explore this relationship in the context of the microbiota-gut-target organ axis in health and disease.
引用
收藏
页码:4152 / 4166
页数:15
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