Antioxidant effects of damiana (Turnera diffusa Willd. ex Schult.) in kidney mitochondria from streptozotocin-diabetic rats

被引：9

作者：

Edgar Romualdo, Esquivel-Gutierrez ^{[1
]}

Lilia, Alcaraz-Melendez ^{[1
]}

Rafael, Salgado-Garciglia ^{[2
]}

Alfredo, Saavedra-Molina ^{[2
]}

机构：

[1] Ctr Invest Biol Noroeste CIBNOR SC, La Paz, Mexico

[2] Univ Michoacana, Morelia, Michoacan, Mexico

来源：

NATURAL PRODUCT RESEARCH | 2018年 / 32卷 / 23期

关键词：

Diabetes; mitochondria; oxidative stress; Turnera diffusa; OXIDATIVE STRESS; PATHOGENESIS;

D O I：

10.1080/14786419.2017.1380009

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The antioxidant effects of water-ethanol extract (WEE) from Turnera diffusa (damiana) in kidney mitochondria from experimental streptozotocin-induced diabetes mellitus (STZ-DM) rats was evaluated. STZ-DM rats were orally treated during three and five weeks. After experimental periods, kidney mitochondria were isolated and malondialdehyde (MDA), nitric oxide (NO center dot) and protein nitrosylation levels were measured. Also, blood glucose (BG) and body weight (BW) were recorded. Damiana significantly reduced the MDA and NO center dot levels in kidney mitochondria, although no changes in protein nitrosylation were observed and it did not have the potential to reverse the hyperglycaemia. In conclusion, WEE of T. diffusa have antioxidant properties that may prevent damage induced by mitochondrial oxidative stress in kidneys of STZ-DM rats. [GRAPHICS] .

引用

页码：2840 / 2843

页数：4

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