MYCT1 alters the glycogen shunt by regulating selective translation of RACK1-mediated enzymes

被引：6

作者：

Ding, Dong-Xue ^{[1
]}

Wang, Yue ^{[1
]}

Yan, Wei ^{[2
]}

Fu, Wei-Neng ^{[1
]}

机构：

[1] China Med Univ, Dept Med Genet, Shenyang, Peoples R China

[2] Harbor UCLA Med Ctr, Lundquist Inst Biomed Innovat, Torrance, CA 90509 USA

来源：

ISCIENCE | 2022年 / 25卷 / 03期

基金：

中国国家自然科学基金;

关键词：

PYRUVATE-KINASE; METABOLISM; HOMEOSTASIS; PROTEINS; SUPPORTS; CELLS; M2;

D O I：

10.1016/j.isci.2022.103955

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

MYCT1 has been shown to function as a tumor suppressor in various tumors, but its role in metabolism has never been reported. Here, we showed that global inactivation of Myct1 in mice led to progressive accumulation of glycogen in the liver, which was accompanied by aberrant changes in intermediates of the glycogen metabolic pathway. Mechanistically, MYCT1 appeared to promote translation efficiency of PGM1, UGP2 and GSK3A in hepatic cells in a RACK1-dependent manner. Consequently, upregulation of the three enzymes enhanced the glycogen shunt. Our data reveal a critical role of MYCT1 as a switch for the glycogen shunt in tumor cells.

引用

页数：18

共 37 条

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