Alterations in MurM, a cell wall muropeptide branching enzyme, increase high-level penicillin and cephalosporin resistance in Streptococcus pneumoniae

被引：70

作者：

Smith, AM

Klugman, KP

机构：

[1] S African Inst Med Res, Dept Clin Microbiol & Infect Dis, Pneumoccal Dis Res Unit, MRC SAIMR WITS, ZA-2000 Johannesburg, South Africa

[2] Emory Univ, Dept Int Hlth, Atlanta, GA 30322 USA

[3] Emory Univ, Dept Infect Dis, Atlanta, GA 30322 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 08期

关键词：

D O I：

10.1128/AAC.45.8.2393-2396.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report that alteration in MurM, an enzyme involved in the biosynthesis of branched-stem cell wall muropeptides, is required for maximal expression of penicillin and cefotaxime resistance in the pneumococcus. Hungarian isolate 3191 (penicillin MIG, 16 mug/ml; cefotaxime MIG, 4 mug/ml) was a source of donor DNA in transformation experiments. Penicillin-binding protein DNA was insufficient to transform recipient strain R6 to full resistance. Further transformation with altered murM DNA was required for full expression of donor penicillin and cefotaxime resistance.

引用

页码：2393 / 2396

页数：4

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