Novel inflammatory mechanisms of accelerated atherosclerosis in kidney disease

被引：60
|
作者：
Swaminathan, Sundararaman [1 ,2 ]
Shah, Sudhir V. [1 ,2 ]
机构：
[1] Univ Arkansas Med Sci, Div Nephrol, Little Rock, AR 72205 USA
[2] Cent Arkansas Veteran Affairs Hlth Syst, Little Rock, AR USA
来源：
KIDNEY INTERNATIONAL | 2011年 / 80卷 / 05期
关键词：
acute kidney injury; cardiovascular disease; chronic kidney disease; inflammation; LOW-DENSITY-LIPOPROTEIN; STAGE RENAL-DISEASE; ISCHEMIA-REPERFUSION INJURY; REGULATORY T-CELLS; E-KNOCKOUT MICE; NONTRADITIONAL RISK-FACTORS; SMOOTH-MUSCLE CELLS; APOE-DEFICIENT MICE; SERUM AMYLOID-A; CARDIOVASCULAR-DISEASE;
D O I：
10.1038/ki.2011.178
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
A substantial body of evidence has accumulated linking an increased incidence of cardiovascular disease in patients with acute kidney injury (AKI), chronic kidney disease (CKD), and end-stage renal disease (ESRD). A multitude of novel risk factors related to decreased kidney function might interact with the renal and systemic immune systems involved in renal injury and repair to participate in accelerated atherogenesis (Immune inflammation-Renal injuryAtherosclerosis-the IRA Paradigm). In this review, we will discuss several of these novel risk factors and present the potential for the role of the immune-inflammatory system in accelerated atherosclerosis of kidney disease. Kidney International (2011) 80, 453-463; doi:10.1038/ki.2011.178; published online 22 June 2011
引用
收藏
页码：453 / 463
页数：11
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