Beyond the brush border: NHERF4 blazes new NHERF turf

被引：34

作者：

Thelin, WR

Hodson, CA

Milgram, SL

机构：

[1] Univ N Carolina, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Grad Program Cell & Mol Physiol, Chapel Hill, NC USA

来源：

JOURNAL OF PHYSIOLOGY-LONDON | 2005年 / 567卷 / 01期

关键词：

D O I：

10.1113/jphysiol.2005.091041

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The Na exchanger regulatory factor (NHERF) family of epithelial-enriched PDZ domain scaffolding proteins plays important roles in maintaining and regulating epithelial cell function. The NHERFs exhibit some overlap in tissue distribution and binding partners, suggesting redundant functions. Yet, it is clear that each NHERF protein exhibits distinct properties, translating into unique cellular functions. The work summarized in this review suggests the most recently identified family member, NHERF4, is the most divergent. Additional investigation is needed, however, to understand more completely the role of NHERF4 in the context of the NHERF family.

引用

页码：13 / 19

页数：7

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