Highly durable enantio-differentiating nickel catalyst for repeated use for the hydrogenation of methyl acetoacetate

被引：15
作者：
Osawa, T [1 ]
Sakai, S
Harada, T
Takayasu, O
机构：
[1] Toyama Univ, Fac Sci, Toyama 9308555, Japan
[2] Ryukoku Univ, Fac Sci & Technol, Otsu, Shiga 5202194, Japan
来源：
CHEMISTRY LETTERS | 2001年 / 05期
关键词：
D O I：
10.1246/cl.2001.392
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The enantio-differentiating hydrogenation of methyl acetoacetate was repeated 30 times over a fine Ni powder catalyst while modifiers (optically active tartaric acid and NaBr) were directly added to the reaction media only in the first run. Over 80% optical yields were attained for the repeated runs. The addition of sodium 2-ethylhexanoate increased the optical yields in the subsequent runs. The very simple and highly durable enantio-differentiating nickel catalyst for repeated use was developed by an in situ modification.
引用
收藏
页码：392 / 393
页数：2
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