Nonmotor Symptoms in Huntington Disease

被引：14

作者：

Cardoso, Francisco ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil

来源：

NONMOTOR PARKINSON'S: THE HIDDEN FACE - MANAGEMENT AND THE HIDDEN FACE OF RELATED DISORDERS | 2017年 / 134卷

关键词：

SUICIDAL IDEATION; TRACK-HD; PREMANIFEST; DIAGNOSIS; SLEEP; PREVALENCE; PATHOLOGY; COGNITION; CARRIERS; COMMON;

D O I：

10.1016/bs.irn.2017.05.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Huntington disease (HD) is characterized by the triad of motor abnormalities, cognitive dysfunction, and behavioral changes. The aim of this chapter is to describe the frequency, clinical features, and management of behavioral and cognitive dysfunction in HD. Depression, suicidal ideation, apathy, irritability, aggressiveness, obsessions, and compulsions are the most common behavioral abnormalities in HD. All HD patients develop cognitive decline. Recent data suggest that these nonmotor changes are found in premanifest HD gene carriers. Finally, we review the therapeutic options available for behavioral and cognitive abnormalities in HD. The management of these conditions is based on experts' agreement since there is a lack of empirical data.

引用

页码：1397 / 1408

页数：12

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