Estrogen metabolites in a small cohort of patients with idiopathic pulmonary arterial hypertension

被引：19

作者：

Denver, Nina ^{[1
,2
]}

Horner, Natalie Z. M. ^{[2
]}

Andrew, Ruth ^{[2
,3
]}

Harvey, Katie Y. ^{[1
]}

Morrell, Nicholas ^{[4
]}

Austin, Eric D. ^{[5
]}

MacLean, Margaret R. ^{[6
]}

机构：

[1] Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland

[2] Queens Med Res Inst, Edinburgh Clin Res Facil, Mass Spectrometry Core, Edinburgh, Midlothian, Scotland

[3] Queens Med Res Inst, Univ BHF Ctr Cardiovasc Sci, Edinburgh, Midlothian, Scotland

[4] Univ Cambridge, Dept Med, Cambridge, England

[5] Vanderbilt Univ, Med Ctr, Dept Pediat, Nashville, TN 37232 USA

[6] Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, HW406,Hamnett Wing,161,Cathedral St, Glasgow G4 0RE, Lanark, Scotland

来源：

PULMONARY CIRCULATION | 2020年 / 10卷 / 01期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会; 美国国家卫生研究院;

关键词：

pulmonary hypertension experimental; metabolism; sex; pulmonary hypertension; 16-ALPHA-HYDROXYESTRONE; ESTRADIOL;

D O I：

10.1177/2045894020908783

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Increased risk and severity of idiopathic pulmonary arterial hypertension (iPAH) is associated with elevated estradiol in men and postmenopausal women. Pulmonary arteries synthesise estradiol via aromatase and metabolise it via CYP1B1 to mitogenic metabolites; SNPs in aromatase and CYP1B1 have been associated with PAH. This suggests that estradiol metabolism could be altered in iPAH. This proof-of-concept study profiles estradiol and several metabolites of estradiol simultaneously in serum from iPAH patients and controls. We show that the estradiol and metabolite profile is altered in iPAH and that 16-hydroxyestrone and 16-hydroxyestradiol accumulate in iPAH patients with 16-hydroxyestrone levels relating to disease severity.

引用

页数：5

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