BMS-345541 inhibited nuclear factor kappa B expression and improved locomotor function recovery in rats after acute spinal cord injury

被引：12
作者：
Han, Xin [1 ]
Wang, Shouyu [1 ]
Zhang, Zhen [1 ]
Lu, Decheng [1 ]
Liu, Hairun [1 ]
机构：
[1] Dalian Med Univ, Dept Orthoped Surg, Affiliated Hosp 1, Dalian 116000, Liaoning Provin, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2011年 / 6卷 / 23期
关键词：
spinal cord injury; BMS-345541; nuclear factor kappa B; locomotor function; neural regeneration; INFLAMMATORY RESPONSE; CELL-DEATH; KINASE; ACTIVATION; APOPTOSIS; IKK; P65; METHYLPREDNISOLONE; NEURONS; MODEL;
D O I：
10.3969/j.issn.1673-5374.2011.23.002
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
This study sought to elucidate the changes of nuclear factor kappa B (NF-kappa B) expression and locomotor function of hind limb after subdural injection of BMS-345541 was applied in rats with acute spinal cord injury. The results indicated that BMS-345541 treatment reduced the expression of NF-kB at 24 hours after injury, compared with normal saline-treated rats. This treatment also led to a significant improvement in locomotor functional recovery at 14 days after injury. Overall, the findings demonstrated that BMS-345541 significantly ameliorated spinal cord injury-induced hind limb dysfunction by inhibiting the expression of NF-kB after spinal cord injury.
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收藏
页码：1775 / 1779
页数：5
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