Neutrophil-inspired propulsion in a combined acoustic and magnetic field

被引:168
作者
Ahmed, Daniel [1 ]
Baasch, Thierry [2 ]
Blondel, Nicolas [1 ]
Laubli, Nino [1 ]
Dual, Jurg [2 ]
Nelson, Bradley J. [1 ]
机构
[1] Swiss Fed Inst Technol, Inst Robot & Intelligent Syst, CH-8092 Zurich, Switzerland
[2] Swiss Fed Inst Technol, Inst Mech Syst, CH-8092 Zurich, Switzerland
来源
NATURE COMMUNICATIONS | 2017年 / 8卷
基金
欧洲研究理事会;
关键词
BUBBLE; DRIVEN; WAVES; WATER; CELL; ACOUSTOPHORESIS; MANIPULATION; MICROROBOTS; MICROMOTORS; ACTIVATION;
D O I
10.1038/s41467-017-00845-5
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Systems capable of precise motion in the vasculature can offer exciting possibilities for applications in targeted therapeutics and non-invasive surgery. So far, the majority of the work analysed propulsion in a two-dimensional setting with limited controllability near boundaries. Here we show bio-inspired rolling motion by introducing superparamagnetic particles in magnetic and acoustic fields, inspired by a neutrophil rolling on a wall. The particles self-assemble due to dipole-dipole interaction in the presence of a rotating magnetic field. The aggregate migrates towards the wall of the channel due to the radiation force of an acoustic field. By combining both fields, we achieved a rolling-type motion along the boundaries. The use of both acoustic and magnetic fields has matured in clinical settings. The combination of both fields is capable of overcoming the limitations encountered by single actuation techniques. We believe our method will have far-reaching implications in targeted therapeutics.
引用
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页数:8
相关论文
共 61 条
  • [1] Artificial Acousto-Magnetic Soft Microswimmers
    Ahmed, Daniel
    Dillinger, Cornel
    Hong, Ayoung
    Nelson, Bradley J.
    [J]. ADVANCED MATERIALS TECHNOLOGIES, 2017, 2 (07):
  • [2] Artificial Swimmers Propelled by Acoustically Activated Flagella
    Ahmed, Daniel
    Baasch, Thierry
    Jang, Bumjin
    Pane, Salvador
    Dual, Juerg
    Nelson, Bradley J.
    [J]. NANO LETTERS, 2016, 16 (08) : 4968 - 4974
  • [3] Rotational manipulation of single cells and organisms using acoustic waves
    Ahmed, Daniel
    Ozcelik, Adem
    Bojanala, Nagagireesh
    Nama, Nitesh
    Upadhyay, Awani
    Chen, Yuchao
    Hanna-Rose, Wendy
    Huang, Tony Jun
    [J]. NATURE COMMUNICATIONS, 2016, 7
  • [4] Selectively manipulable acoustic-powered microswimmers
    Ahmed, Daniel
    Lu, Mengqian
    Nourhani, Amir
    Lammert, Paul E.
    Stratton, Zak
    Muddana, Hari S.
    Crespi, Vincent H.
    Huang, Tony Jun
    [J]. SCIENTIFIC REPORTS, 2015, 5
  • [5] Acoustofluidic Chemical Waveform Generator and Switch
    Ahmed, Daniel
    Muddana, Hari S.
    Lu, Mengqian
    French, Jarrod B.
    Ozcelik, Adem
    Fang, Ye
    Butler, Peter J.
    Benkovic, Stephen J.
    Manz, Andreas
    Huang, Tony Jun
    [J]. ANALYTICAL CHEMISTRY, 2014, 86 (23) : 11803 - 11810
  • [6] Tunable, pulsatile chemical gradient generation via acoustically driven oscillating bubbles
    Ahmed, Daniel
    Chan, Chung Yu
    Lin, Sz-Chin Steven
    Muddana, Hari S.
    Nama, Nitesh
    Benkovic, Stephen J.
    Huang, Tony Jun
    [J]. LAB ON A CHIP, 2013, 13 (03) : 328 - 331
  • [7] A fast microfluidic mixer based on acoustically driven sidewall-trapped microbubbles
    Ahmed, Daniel
    Mao, Xiaole
    Juluri, Bala Krishna
    Huang, Tony Jun
    [J]. MICROFLUIDICS AND NANOFLUIDICS, 2009, 7 (05) : 727 - 731
  • [8] A millisecond micromixer via single-bubble-based acoustic streaming
    Ahmed, Daniel
    Mao, Xiaole
    Shi, Jinjie
    Juluri, Bala Krishna
    Huang, Tony Jun
    [J]. LAB ON A CHIP, 2009, 9 (18) : 2738 - 2741
  • [9] [Anonymous], 2010, BASICS BIOMEDICAL UL
  • [10] Multibody dynamics in acoustophoresis
    Baasch, Thierry
    Leibacher, Ivo
    Dual, Jurg
    [J]. JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 2017, 141 (03) : 1664 - 1674