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Chinese Acad Med Sci & Peking Union Med Coll, Natl Hlth Commiss Key Lab Clin Res Cardiovasc Med, State Key Lab Cardiovasc Dis, Natl Ctr Cardiovasc Dis,Fuwai Hosp,Natl Clin Res C, Beijing 100037, Peoples R China Chinese Acad Med Sci & Peking Union Med Coll, Natl Hlth Commiss Key Lab Clin Res Cardiovasc Med, State Key Lab Cardiovasc Dis, Natl Ctr Cardiovasc Dis,Fuwai Hosp,Natl Clin Res C, Beijing 100037, Peoples R China