Natural killer T cells in lipoprotein metabolism and atherosclerosis

被引：28

作者：

Getz, Godfrey S. ^{[1
]}

VanderLaan, Paul A. ^{[1
]}

Reardon, Catherine A. ^{[1
]}

机构：

[1] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

来源：

THROMBOSIS AND HAEMOSTASIS | 2011年 / 106卷 / 05期

关键词：

Atherosclerosis; CD1d; NKT cells; NKT CELLS; ANTIGEN PRESENTATION; IMMUNE-RESPONSE; INVARIANT; ACTIVATION; DEFICIENCY; SYSTEM; MICE; ISOGLOBOTRIHEXOSYLCERAMIDE; INTESTINE;

D O I：

10.1160/TH11-05-0336

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cells of both the innate and adaptive immune system participate in the development of atherosclerosis, a chronic inflammatory disorder of medium and large arteries. Natural killer T (NKT) cells express surface markers characteristic of natural killer cells and conventional T cells and bridge the innate and adaptive immune systems. The development and activation of NKT cells is dependent upon CD1d, a MHC-class I-type molecule that presents lipids, especially glycolipids to the T cell receptors on NKT cells. There are two classes of NKT cells; invariant NKT cells that express a semi-invariant T cell receptor and variant NKT cells. This review summarises studies in murine models in which the effect of the activation, overexpression or deletion of NKT cells or only invariant NKT cells on atherosclerosis has been examined.

引用

页码：814 / 819

页数：6

共 50 条

[1] Apolipoprotein-mediated lipid antigen presentation in B cells provides a pathway for innate help by NKT cells [J].