共 229 条
Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders
被引:1087
作者:

Autry, Anita E.
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h-index: 0
机构:
Univ Texas SW Med Ctr Dallas, Dept Psychiat, 5323 Harry Hines Blvd, Dallas, TX 75390 USA Univ Texas SW Med Ctr Dallas, Dept Psychiat, 5323 Harry Hines Blvd, Dallas, TX 75390 USA

Monteggia, Lisa M.
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h-index: 0
机构:
Univ Texas SW Med Ctr Dallas, Dept Psychiat, 5323 Harry Hines Blvd, Dallas, TX 75390 USA Univ Texas SW Med Ctr Dallas, Dept Psychiat, 5323 Harry Hines Blvd, Dallas, TX 75390 USA
机构:
[1] Univ Texas SW Med Ctr Dallas, Dept Psychiat, 5323 Harry Hines Blvd, Dallas, TX 75390 USA
基金:
美国国家卫生研究院;
关键词:
BDNF VAL66MET POLYMORPHISM;
MESOLIMBIC DOPAMINE SYSTEM;
RUBINSTEIN-TAYBI-SYNDROME;
FAMILY-BASED ASSOCIATION;
NERVE GROWTH-FACTOR;
FACTOR GENE BDNF;
BODY-MASS-INDEX;
ANTIDEPRESSANT DRUG TREATMENTS;
SEROTONIN TRANSPORTER FUNCTION;
VENTRAL HIPPOCAMPAL LESION;
D O I:
10.1124/pr.111.005108
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
Brain derived neurotrophic factor (BDNF) is the most prevalent growth factor in the central nervous system (CNS). It is essential for the development of the CNS and for neuronal plasticity. Because BDNF plays a crucial role in development and plasticity of the brain, it is widely implicated in psychiatric diseases. This review provides a summary of clinical and preclinical evidence for the involvement of this ubiquitous growth factor in major depressive disorder, schizophrenia, addiction, Rett syndrome, as well as other psychiatric and neurodevelopmental diseases. In addition, the review includes a discussion of the role of BDNF in the mechanism of action of pharmacological therapies currently used to treat these diseases, such antidepressants and antipsychotics. The review also covers a critique of experimental therapies such as BDNF mimetics and discusses the value of BDNF as a target for future drug development.
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收藏
页码:238 / 258
页数:21
相关论文
共 229 条
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