Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders

被引:1087
作者
Autry, Anita E. [1 ]
Monteggia, Lisa M. [1 ]
机构
[1] Univ Texas SW Med Ctr Dallas, Dept Psychiat, 5323 Harry Hines Blvd, Dallas, TX 75390 USA
基金
美国国家卫生研究院;
关键词
BDNF VAL66MET POLYMORPHISM; MESOLIMBIC DOPAMINE SYSTEM; RUBINSTEIN-TAYBI-SYNDROME; FAMILY-BASED ASSOCIATION; NERVE GROWTH-FACTOR; FACTOR GENE BDNF; BODY-MASS-INDEX; ANTIDEPRESSANT DRUG TREATMENTS; SEROTONIN TRANSPORTER FUNCTION; VENTRAL HIPPOCAMPAL LESION;
D O I
10.1124/pr.111.005108
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Brain derived neurotrophic factor (BDNF) is the most prevalent growth factor in the central nervous system (CNS). It is essential for the development of the CNS and for neuronal plasticity. Because BDNF plays a crucial role in development and plasticity of the brain, it is widely implicated in psychiatric diseases. This review provides a summary of clinical and preclinical evidence for the involvement of this ubiquitous growth factor in major depressive disorder, schizophrenia, addiction, Rett syndrome, as well as other psychiatric and neurodevelopmental diseases. In addition, the review includes a discussion of the role of BDNF in the mechanism of action of pharmacological therapies currently used to treat these diseases, such antidepressants and antipsychotics. The review also covers a critique of experimental therapies such as BDNF mimetics and discusses the value of BDNF as a target for future drug development.
引用
收藏
页码:238 / 258
页数:21
相关论文
共 229 条
[1]   Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy [J].
Adachi, Megumi ;
Barrot, Michel ;
Autry, Anita E. ;
Theobald, David ;
Monteggia, Lisa M. .
BIOLOGICAL PSYCHIATRY, 2008, 63 (07) :642-649
[2]   MeCP2-Mediated Transcription Repression in the Basolateral Amygdala May Underlie Heightened Anxiety in a Mouse Model of Rett Syndrome [J].
Adachi, Megumi ;
Autry, Anita E. ;
Covington, Herb E., III ;
Monteggia, Lisa M. .
JOURNAL OF NEUROSCIENCE, 2009, 29 (13) :4218-4227
[3]   Gender differences in the enhanced vulnerability of BDNF+/- mice to mild stress [J].
Advani, Tushar ;
Koek, Wouter ;
Hensler, Julie G. .
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2009, 12 (05) :583-588
[4]   Mouse and rat BDNF gene structure and expression revisited [J].
Aid, Tamara ;
Kazantseva, Anna ;
Piirsoo, Marko ;
Palm, Kaia ;
Timmusk, Tonis .
JOURNAL OF NEUROSCIENCE RESEARCH, 2007, 85 (03) :525-535
[5]   Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons [J].
Akbarian, S ;
Rios, M ;
Liu, RJ ;
Gold, SJ ;
Fong, HF ;
Zeiler, S ;
Coppola, V ;
Tessarollo, L ;
Jones, KR ;
Nestler, EJ ;
Aghajanian, GK ;
Jaenisch, R .
JOURNAL OF NEUROSCIENCE, 2002, 22 (10) :4153-4162
[6]   Effects of electroconvulsive seizures and antidepressant drugs on brain-derived neurotrophic factor protein in rat brain [J].
Altar, CA ;
Whitehead, RE ;
Chen, RY ;
Wörtwein, G ;
Madsen, TM .
BIOLOGICAL PSYCHIATRY, 2003, 54 (07) :703-709
[7]   Transient receptor potential channels as novel effectors of brain-derived neurotrophic factor signaling: Potential implications for Rett syndrome [J].
Amaral, Michelle D. ;
Chapleau, Christopher A. ;
Pozzo-Miller, Lucas .
PHARMACOLOGY & THERAPEUTICS, 2007, 113 (02) :394-409
[8]   Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2 [J].
Amir, RE ;
Van den Veyver, IB ;
Wan, M ;
Tran, CQ ;
Francke, U ;
Zoghbi, HY .
NATURE GENETICS, 1999, 23 (02) :185-188
[9]   Effect of 7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, on Emotional Learning [J].
Andero, Raul ;
Heldt, Scott A. ;
Ye, Keqiang ;
Liu, Xia ;
Armario, Antonio ;
Ressler, Kerry J. .
AMERICAN JOURNAL OF PSYCHIATRY, 2011, 168 (02) :163-172
[10]   DIFFERENTIAL DISTRIBUTION OF EXOGENOUS BDNF, NGF, AND NT-3 IN THE BRAIN CORRESPONDS TO THE RELATIVE ABUNDANCE AND DISTRIBUTION OF HIGH-AFFINITY AND LOW-AFFINITY NEUROTROPHIN RECEPTORS [J].
ANDERSON, KD ;
ALDERSON, RF ;
ALTAR, CA ;
DISTEFANO, PS ;
CORCORAN, TL ;
LINDSAY, RM ;
WIEGAND, SJ .
JOURNAL OF COMPARATIVE NEUROLOGY, 1995, 357 (02) :296-317