Potassium channel blockers from the venom of the Brazilian scorpion Tityus serrulatus (Lutz and Mello, 1922)

被引：16

作者：

Martin-Eauclaire, Marie-France ^{[1
]}

Pimenta, Adriano M. C. ^{[2
]}

Bougis, Pierre E. ^{[1
]}

De Lima, Maria-Elena ^{[2
]}

机构：

[1] Aix Marseille Univ, CNRS, CRN2M, UMR7286, F-13344 Marseille, France

[2] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, Lab Venenos & Toxinas Anim, BR-31270901 Belo Horizonte, MG, Brazil

来源：

TOXICON | 2016年 / 119卷

关键词：

Potassium channels; Tityus serrulatus; Scorpion toxins; Blockers; CA2+-ACTIVATED K+ CHANNELS; MOVING PIECES; THERAPEUTIC TARGET; ALPHA-DENDROTOXIN; PEPTIDE TOXINS; APAMIN-BINDING; HIGH-AFFINITY; BETA-TOXIN; RAT-BRAIN; PURIFICATION;

D O I：

10.1016/j.toxicon.2016.06.016

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Potassium (K+) channels are trans-membrane proteins, which play a key role in cellular excitability and signal transduction pathways. Scorpion toxins blocking the ion-conducting pore from the external side have been invaluable probes to elucidate the structural, functional, and physio-pathological characteristics of these ion channels. This review will focus on the interaction between K+ channels and their peptide blockers isolated from the venom of the scorpion Tityus serrulatus, which is considered as the most dangerous scorpion in Brazil, in particular in Minas-Gerais State, where many casualties are described each year. The primary mechanisms of action of these K+ blockers will be discussed in correlation with their structure, very often non-canonical compared to those of other well known K+ channels blockers purified from other scorpion venoms. Also, special attention will be brought to the most recent data obtained by proteomic and transcriptomic analyses on Tityus serrulatus venoms and venom glands. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：253 / 265

页数：13

共 74 条

[51] Moving pieces in a taxonomic puzzle: Venom 2D-LC/MS and data clustering analyses to infer phylogenetic relationships in some scorpions from the Buthidae family (Scorpiones) [J].

Nascimento, Danielle G. ;

Rates, Breno ;

Santos, Daniel M. ;

Verano-Braga, Thiago ;

Barbosa-Silva, Adriano ;

Dutra, Alexandre A. A. ;

Biondi, Ilka ;

Martin-Eauclaire, Marie France ;

De Lima, Maria Elena ;

Pimenta, Adriano M. C. .

TOXICON, 2006, 47 (06) :628-639

[52] TsTX-IV, a short chain four-disulfide-bridged neurotoxin from Tityus serrulatus venom which acts on Ca2+-activated K+ channels [J].

Novello, JC ;

Arantes, EC ;

Varanda, WA ;

Oliveira, B ;

Giglio, JR ;

Marangoni, S .

TOXICON, 1999, 37 (04) :651-660

[53] Another record of significant regional variation in toxicity of Tityus serrulatus venom in Brazil: A step towards understanding the possible role of sodium channel modulators [J].

Oliveira, Fagner Neves ;

Mortari, Marcia Renata ;

Carneiro, Fabiana Pirani ;

Guerrero-Vargas, Jimmy Alexander ;

Santos, Daniel M. ;

Pimenta, Adriano M. C. ;

Schwartz, Elisabeth E. .

TOXICON, 2013, 73 :33-46

[54] Probing the pH-dependent structural features of α-KTx12.1, a potassium channel blocker from the scorpion Tityus serrulatus [J].

Oyama, S ;

Pristovsek, P ;

Franzoni, L ;

Pertinhez, TA ;

Schininá, E ;

Lücke, C ;

Rüterjans, H ;

Arantes, EC ;

Spisni, A .

PROTEIN SCIENCE, 2005, 14 (04) :1025-1038

[55] Novel structural class of four disulfide-bridged peptides from Tityus serrulatus venom [J].

Pimenta, AMC ;

Legros, C ;

Almeida, FD ;

Mansuelle, P ;

De Lima, ME ;

Bougis, PE ;

Martin-Eauclaire, MF .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 301 (04) :1086-1092

[56] Covalent structure and some pharmacological features of native and cleaved α-KTx12-1, a four disulfide-bridged toxin from Tityus serrulatus venom [J].

Pimenta, AMC ;

Mansuelle, P ;

Diniz, CR ;

Martin-Eauclaire, MF .

JOURNAL OF PEPTIDE SCIENCE, 2003, 9 (02) :132-140

[57] Individual variability in Tityus serrulatus (Scorpiones, Buthidae) venom elicited by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry [J].

Pimenta, AMC ;

Almeida, FD ;

de Lima, ME ;

Martin-Eauclaire, MF ;

Bougis, PE .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2003, 17 (05) :413-418

[58] Moving pieces in a proteomic puzzle:: mass fingerprinting of toxic fractions from the venom of Tityus serrulatus (Scorpiones, Buthidae) [J].

Pimenta, AMC ;

Stöcklin, R ;

Favreau, P ;

Bougis, PE ;

Martin-Eauclaire, MF .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2001, 15 (17) :1562-1572

[59]

Pongs O., 2007, REGULATION EXCITABIL, P145

[60]

POSSANI LD, 1977, ARCH BIOCHEM BIOPHYS, V180, P394, DOI 10.1016/0003-9861(77)90053-4

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