Viridistratins A-C, Antimicrobial and Cytotoxic Benzo[j]fluoranthenes from Stromata of Annulohypoxylon viridistratum (Hypoxylaceae, Ascomycota)

被引：53

作者：

Becker, Kevin ^{[1
,2
]}

Wessel, Anna-Charleen ^{[1
]}

Luangsa-ard, J. Jennifer ^{[3
]}

Stadler, Marc ^{[1
,2
]}

机构：

[1] Helmholtz Ctr Infect Res GmbH HZI, Dept Microbial Drugs, Inhoffenstr 7, D-38124 Braunschweig, Germany

[2] German Ctr Infect Res Assoc DZIF, Partner Site Hannover Braunschweig,Inhoffenstr 7, D-38124 Braunschweig, Germany

[3] Natl Ctr Genet Engn & Biotechnol BIOTEC, 113 Thailand Sci Pk,Phahonyothin Rd, Khlong Luang 12120, Pathum Thani, Thailand

来源：

BIOMOLECULES | 2020年 / 10卷 / 05期

基金：

欧盟地平线“2020”;

关键词：

Ascomycota; benzo[j]fluoranthenes; chemotaxonomy; chromatography; secondary metabolites; structure elucidation; Xylariales; MUSHROOM;

D O I：

10.3390/biom10050805

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During the course of our search for novel biologically active metabolites from tropical fungi, we are using chemotaxonomic and taxonomic methodology for the preselection of interesting materials. Recently, three previously undescribed benzo[j]fluoranthenes (1-3) together with the known derivatives truncatones A and C (4, 5) were isolated from the stromata of the recently described species Annulohypoxylon viridistratum collected in Thailand. Their chemical structures were elucidated by means of spectral methods, including nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry (HR-MS). The new compounds, for which we propose the trivial names viridistratins A-C, exhibited weak-to-moderate antimicrobial and cytotoxic activities in cell-based assays.

引用

页数：11

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