Microwave assisted synthesis and in vitro antimicrobial assessment of quinolone based s-triazines

A series of 1,3,5-triazine derivatives that contain aniline, 4-hydroxy-N-methylquinolone and different piperazine and piperidine moieties as substituents on the carbon atoms of the triazine ring has been synthesized by a simple and efficient synthetic protocol. Comparative studies were performed on the compounds, which were synthesized with conventional and microwave heating methods. The microwave method was observed to be more beneficial as it provides an increase in yield and 90%-95% reduction time. The antimicrobial activity of the compounds was tested against seven bacteria (Staphylococcus aureus, Bacillus cereus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, Salmonella typhi, Proteus vulgaris) and two fungi (Aspergillus niger, Candida albicans). The results indicate that some of the novel s-triazines have noteworthy activity in MIC and agar diffusion tests.