Balancing antimicrobial performance with hemocompatibility in amphiphilic homopolymers

被引：9

作者：

Zhu, Zhiyuan ^{[1
]}

Jeong, Gookyeong ^{[1
]}

Kim, Seung-Jin ^{[1
]}

Gadwal, Ikhlas ^{[2
]}

Choe, Youngson ^{[3
]}

Bang, Joona ^{[1
]}

Oh, Min-Kyu ^{[1
]}

Khan, Anzar ^{[1
]}

Rao, Jingyi ^{[1
]}

机构：

[1] Korea Univ, Dept Chem & Biol Engn, Seoul 02841, South Korea

[2] Natl Chem Lab, CSIR, Polymer Sci & Engn Div, Polymers & Adv Mat Lab, Pune 411008, Maharashtra, India

[3] Pusan Natl Univ, Dept Chem Engn, Pusan 46241, South Korea

来源：

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY | 2018年 / 56卷 / 21期

基金：

新加坡国家研究基金会;

关键词：

amphiphilic polymers; antibacterial polymers; poly(glycidyl methacrylate); sequential post-polymerization modification; thiol-epoxy reaction; DE-NOVO DESIGN; POST-POLYMERIZATION MODIFICATION; THIOL-EPOXY; POSTPOLYMERIZATION MODIFICATION; HEMOLYTIC ACTIVITIES; SYNTHETIC MIMICS; POLYMERS; ANTIBACTERIAL; COPOLYMERS; DERIVATIVES;

D O I：

10.1002/pola.29213

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

This work establishes amphiphilic polymethacrylates as new antimicrobial candidates that can be synthesized through a combination of controlled free radical polymerization and sequential postpolymerization modification protocols. When conjugated with a polyethylene glycol segment, the block copolymers exhibit a balanced performance between high antibacterial activity and high hemocompatibility.

引用

页码：2391 / 2396

页数：6

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