T Cells in Nonlymphoid Tissues Give Rise to Lymph-Node-Resident Memory T Cells

被引：201

作者：

Beura, Lalit K. ^{[1
,2
]}

Wijeyesinghe, Sathi ^{[1
,2
]}

Thompson, Emily A. ^{[1
,2
]}

Macchietto, Marissa G. ^{[3
]}

Rosato, Pamela C. ^{[1
,2
]}

Pierson, Mark J. ^{[1
,2
]}

Schenkel, Jason M. ^{[1
,2
,6
]}

Mitchell, Jason S. ^{[2
,4
]}

Vezys, Vaiva ^{[1
,2
]}

Fife, Brian T. ^{[2
,5
]}

Shen, Steven ^{[3
]}

Masopust, David ^{[1
,2
]}

机构：

[1] Univ Minnesota, Dept Microbiol & Immunol, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Ctr Immunol, Minneapolis, MN 55455 USA

[3] Univ Minnesota, Inst Hlth Informat, Minneapolis, MN 55455 USA

[4] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA

[5] Univ Minnesota, Dept Med, Box 736 UMHC, Minneapolis, MN 55455 USA

[6] Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA

来源：

IMMUNITY | 2018年 / 48卷 / 02期

基金：

美国国家卫生研究院;

关键词：

MOLECULAR SIGNATURE; RECALL RESPONSES; CUTTING EDGE; IN-VIVO; SKIN; DIFFERENTIATION; ORGANS; MICE; COMPARTMENTALIZATION; MAINTENANCE;

D O I：

10.1016/j.immuni.2018.01.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunosurveillance of secondary lymphoid organs (SLO) is performed by central memory T cells that recirculate through blood. Resident memory T (Trm) cells remain parked in nonlymphoid tissues and often stably express CD69. We recently identified Trm cells within SLO, but the origin and phenotype of these cells remains unclear. Using parabiosis of "dirty'' mice, we found that CD69 expression is insufficient to infer stable residence of SLO Trm cells. Restimulation of nonlymphoid memory CD8(+) T cells within the skin or mucosa resulted in a substantial increase in bona fide Trm cells specifically within draining lymph nodes. SLO Trm cells derived from emigrants from nonlymphoid tissues and shared some transcriptional and phenotypic signatures associated with nonlymphoid Trm cells. These data indicate that nonlymphoid cells can give rise to SLO Trm cells and suggest vaccination strategies by which memory CD8(+) T cell immunosurveillance can be regionalized to specific lymph nodes.

引用

收藏

页码：327 / +

页数：17

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