Synthesis and crystal structure of (4bRS,9bRS)-5-(2,4-dimethoxyphenyl)-4b,9b-7,7-dimethyldihydroxy-4b,5,6,7,8,9b-hexahydroindeno[1,2-b]indole-9,10-dione

被引：8

作者：

Lobo, Gricela ^{[1
]}

Zuleta, Elimar ^{[1
]}

Charris, Katiuska ^{[1
]}

Capparelli, Mario V. ^{[2
]}

Briceno, Alexander ^{[3
]}

Angel, Jorge ^{[4
]}

Charris, Jaime ^{[1
]}

机构：

[1] Cent Univ Venezuela, Fac Farm, Lab Sintesis Organ, Caracas 1041A, Venezuela

[2] Fdn Inst Estudios Avanzados IDEA, Unidad Estruct Mol, Caracas 1015A, Venezuela

[3] Inst Venezolano Invest Cient, Lab Sintesis & Caracterizac Nuevos Mat, Caracas 1020A, Venezuela

[4] Univ Zulia, Fac Ciencias Expt, Dpto Quim, Lab Sintesis Organ & Diseno Farmacos, Maracaibo 4011, Venezuela

来源：

JOURNAL OF CHEMICAL RESEARCH | 2011年 / 04期

关键词：

indeno[1,2-b]indole; ninhydrin; regiospecific; crystal structure; NATIONAL-CANCER-INSTITUTE; POTENTIAL ANTIMALARIAL; DRUG DISCOVERY; DERIVATIVES; NINHYDRIN; INDOLE; ASSAY;

D O I：

10.3184/174751911X13015834294266

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly regiospecific synthesis and crystal structure of (4bRS,9bRS)-5-(2,4-dimethoxyphenyl)-7,7-dimethyl-4b,9b-dihydroxy-4b,5,6,7,8,9b-hexahydroindeno[1,2-b]indole-9,10-dione is reported. It was tested in vitro against six human tumour cell lines and two nontumourogenic cell lines. Their in vitro activity against Mycobacterium tuberculosis is also reported. In general, it was found to possess a marginal activity.

引用

页码：222 / 224

页数：3

共 27 条

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