Ticket to divide: m6A reader YTHDC1 drives acute myeloid leukemia proliferation

被引：5
|
作者：
Volk, Andrew [1 ]
机构：
[1] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA
来源：
BLOOD | 2021年 / 138卷 / 26期
关键词：
RNA DEMETHYLASE; ALKBH5;
D O I：
10.1182/blood.2021013185
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this issue of Blood, Sheng et al show that the N-6-methyladenosine (m(6)A) messenger RNA (mRNA) reader protein YTH domain containing 1 (YTHDC1) promotes leukemic cell proliferation through stabilizing transcriptions of DNA replication initiation complex subunit MCM4.(1)
引用
收藏
页码：2748 / 2750
页数：3
相关论文
共 50 条
  • [1] Nuclear m6A Reader YTHDC1 Regulates mRNA Splicing
    Roundtree, Ian A.
    He, Chuan
    TRENDS IN GENETICS, 2016, 32 (06) : 320 - +
  • [2] Nuclear m6A Reader YTHDC1 Regulates mRNA Splicing
    Xiao, Wen
    Adhikari, Samir
    Dahal, Ujwal
    Chen, Yu-Sheng
    Hao, Ya-Juan
    Sun, Bao-Fa
    Sun, Hui-Ying
    Li, Ang
    Ping, Xiao-Li
    Lai, Wei-Yi
    Wang, Xing
    Ma, Hai-Li
    Huang, Chun-Min
    Yang, Ying
    Huang, Niu
    Jiang, Gui-Bin
    Wang, Hai-Lin
    Zhou, Qi
    Wang, Xiu-Jie
    Zhao, Yong-Liang
    Yang, Yun-Gui
    MOLECULAR CELL, 2016, 61 (04) : 507 - 519
  • [3] Roles and mechanisms of the m6A reader YTHDC1 in biological processes and diseases
    Huaqing Yan
    Liqi Zhang
    Xiaobo Cui
    Sinian Zheng
    Rubing Li
    Cell Death Discovery, 8
  • [4] Roles and mechanisms of the m6A reader YTHDC1 in biological processes and diseases
    Yan, Huaqing
    Zhang, Liqi
    Cui, Xiaobo
    Zheng, Sinian
    Li, Rubing
    CELL DEATH DISCOVERY, 2022, 8 (01)
  • [5] Flexible Binding of m6A Reader Protein YTHDC1 to Its Preferred RNA Motif
    Li, Yaozong
    Bedi, Rajiv Kumar
    Wiedmer, Lars
    Huang, Danzhi
    Sledz, Pawel
    Caflisch, Amedeo
    JOURNAL OF CHEMICAL THEORY AND COMPUTATION, 2019, 15 (12) : 7004 - 7014
  • [6] m6A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin
    Liang, Diefei
    Lin, Wei-Jye
    Ren, Meng
    Qiu, Junxiong
    Yang, Chuan
    Wang, Xiaoyi
    Li, Na
    Zeng, Tingting
    Sun, Kan
    You, Lili
    Yan, Li
    Wang, Wei
    AUTOPHAGY, 2022, 18 (06) : 1318 - 1337
  • [7] The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity
    Jiadong Liu
    Mingwei Gao
    Jiangping He
    Kaixin Wu
    Siyuan Lin
    Lingmei Jin
    Yaping Chen
    He Liu
    Junjie Shi
    Xiwei Wang
    Lei Chang
    Yingying Lin
    Yu-Li Zhao
    Xiaofei Zhang
    Man Zhang
    Guan-Zheng Luo
    Guangming Wu
    Duanqing Pei
    Jie Wang
    Xichen Bao
    Jiekai Chen
    Nature, 2021, 591 : 322 - 326
  • [8] Downregulation of the m6A reader protein YTHDC1 leads to islet β-cell failure and diabetes
    Li, Xinzhi
    Yang, Ying
    Chen, Zheng
    METABOLISM-CLINICAL AND EXPERIMENTAL, 2023, 138
  • [9] The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity
    Liu, Jiadong
    Gao, Mingwei
    He, Jiangping
    Wu, Kaixin
    Lin, Siyuan
    Jin, Lingmei
    Chen, Yaping
    Liu, He
    Shi, Junjie
    Wang, Xiwei
    Chang, Lei
    Lin, Yingying
    Zhao, Yu-Li
    Zhang, Xiaofei
    Zhang, Man
    Luo, Guan-Zheng
    Wu, Guangming
    Pei, Duanqing
    Wang, Jie
    Bao, Xichen
    Chen, Jiekai
    NATURE, 2021, 591 (7849) : 322 - +
  • [10] Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m6A) Recognition by the Reader Domain of YTHDC1
    Li, Yaozong
    Bedi, Rajiv Kumar
    Wiedmer, Lars
    Sun, Xianqiang
    Huang, Danzhi
    Caflisch, Amedeo
    JOURNAL OF CHEMICAL THEORY AND COMPUTATION, 2021, 17 (02) : 1240 - 1249
12345