The impact of hypertension on retinal nerve fiber layer thickness and its association with carotid intima media thickness

Objective. Our aim was to investigate retinal nerve fi ber layer (RNFL) thickness in hypertensive patients using spectraldomain optical coherence tomography (SD-OCT) and to evaluate the relationship between RNFL thickness and carotid intima media thickness (CIMT). Methods. This study included 59 patients with hypertension (HT) (53.6 +/- 10.7 years) and 54 age-matched healthy controls (51.0 +/- 8.1 years). We evaluated anthropometric and metabolic parameters as well as RNFL and CIMT measurements in patients with hypertension and controls. Results. The average RNFL thickness was 86.60 +/- 10.86 mu m in hypertensive patients and 93.63 +/- 7.30 mu m in healthy controls (p < 0.001). Selective thinning of the RNFL was found in the superior and inferior quadrants. Mean CIMT values were higher in patients with HT (0.80 +/- 0.15 mm) than the healthy subjects (0.71 +/- 0.1 mm) (p < 0.001). The average, inferior and nasal RNFL thickness were negatively associated with diastolic blood pressure respectively (r= 0.112, r= 0.210, r= 0.225). There was an inverse correlation between RNFL thickness in the average and superior retinal quadrant and CIMT (r- =0.201, r= -0.185). There were no correlations between RNFL thickness and age, body mass index, fasting plasma glucose, lipid parameters, high-sensitive C-reactive protein and microalbuminuria. Conclusion. RNFL thickness is reduced in hypertensive patients and may be associated with atherosclerosis.