Expression of copper trafficking genes in the mouse brain

被引：52
|
作者：
Nishihara, E
Furuyama, T
Yamashita, S
Mori, N
机构：
[1] Natl Inst Longev Sci, Dept Mol Genet Res, Aichi 4748522, Japan
[2] Nagasaki Univ, Sch Med, Dept Nat Med, Atom Bomb Dis Inst, Nagasaki 8528102, Japan
来源：
NEUROREPORT | 1998年 / 9卷 / 14期
关键词：
ATP7a; ATX1; CCS; copper; COX17; choroid plexus; CTR1;
D O I：
10.1097/00001756-199810050-00023
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
COPPER homeostasis in the brain must be strictly maintained, since copper is an essential trace element and is potentially toxic. To understand the mechanism of copper homeostasis in the brain, we cloned several mouse homologues of copper trafficking genes and performed in situ hybridization histochemistry. mCTR1, mATX1, and mATP7a were highly expressed in the choroid plexus, indicating that the choroid plexus uses the trafficking pathway from uptake to efflux to transport copper to the cerebrospinal fluids. We suggest that these genes may regulate copper concentration in the brain through the choroid plexus. (C) 1998 Lippincott Williams & Wilkins.
引用
收藏
页码：3259 / 3263
页数：5
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