Clinical and genetic features of familial pituitary adenomas

被引:22
作者
Daly, AF
Jaffrain-Rea, ML
Beckers, A
机构
[1] CHU Liege, Dept Endocrinol, B-4000 Liege, Belgium
[2] Univ Aquila, Dept Expt Med, I-67100 Laquila, Italy
关键词
pituitary; tumor; adenoma; familial;
D O I
10.1055/s-2005-870135
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Inherited or familial pituitary tumor syndromes such as multiple endocrine neoplasia type 1 and Carney complex provide an important insight into the genetics and molecular pathology of endocrine cancers. Our understanding of these conditions is expanding rapidly due to the identification of the genes and proteins affected and the availability of murine knockout models. The successes achieved to date in understanding multiple endocrine neoplasia type 1 and Carney complex have helped in the identification and study of new inherited pituitary tumor syndromes such as isolated familial somatotropinomas. This review assesses the current status of research into the clinical features, genetics and molecular pathologies of multiple endocrine neoplasia type 1, Carney complex, and isolated familial somatotropinomas, and details ongoing work to delineate familial isolated pituitary adenomas, a potentially new clinical entity.
引用
收藏
页码:347 / 354
页数:8
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