Alignment of long DNA molecules on templates generated via dip-pen nanolithography

被引：43
|
作者：
Nyamjav, D
Ivanisevic, A
机构：
[1] Purdue Univ, Dept Biomed Engn, W Lafayette, IN 47907 USA
[2] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA
[3] Purdue Univ, Dept Phys, W Lafayette, IN 47907 USA
来源：
ADVANCED MATERIALS | 2003年 / 15卷 / 21期
关键词：
D O I：
10.1002/adma.200305342
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A methodology to place and stretch long DNA molecules by coupling dip-pen nanolithography with molecular combing is presented. Templates were fabricated on SiOx surfaces using a positively charged polymer, poly(allylamine hydrochloride). Upon molecular combing, DNA molecules elongate on the surface (for example, see Figure) and are localized by the presence of the charged lithographically defined structures.
引用
收藏
页码：1805 / 1809
页数：5
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