Prevalence of Left Ventricular Systolic Dysfunction in Adults With Repaired Tetralogy of Fallot

被引：121

作者：

Broberg, Craig S. ^{[1
]}

Aboulhosn, Jamil ^{[2
]}

Mongeon, Francois-Pierre ^{[3
]}

Kay, Joseph ^{[4
]}

Valente, Anne Marie ^{[5
,6
]}

Khairy, Paul ^{[3
]}

Earing, Michael G. ^{[7
]}

Opotowsky, Alexander R. ^{[5
,6
]}

Lui, George ^{[8
]}

Gersony, Deborah R. ^{[9
]}

Cook, Stephen ^{[10
]}

Ting, Jennifer Grando ^{[11
]}

Webb, Gary ^{[12
]}

Gurvitz, Michelle Z. ^{[5
,6
]}

机构：

[1] Oregon Hlth & Sci Univ, Portland, OR 97201 USA

[2] Univ Calif Los Angeles, Los Angeles, CA USA

[3] Univ Montreal, Montreal Heart Inst, Montreal, PQ H3C 3J7, Canada

[4] Univ Colorado, Denver, CO 80202 USA

[5] Childrens Hosp, Dept Cardiol, Boston, MA 02115 USA

[6] Brigham & Womens Hosp, Div Cardiol, Boston, MA 02115 USA

[7] Med Coll Wisconsin, Milwaukee, WI 53226 USA

[8] Montefiore Med Ctr, Albert Einstein Coll Med, Bronx, NY 10467 USA

[9] Columbia Univ, New York, NY USA

[10] Ohio State Univ, Columbus, OH 43210 USA

[11] Penn State Univ, Milton S Hershey Med Ctr, Hershey, PA 17033 USA

[12] Cincinnati Childrens Hosp, Cincinnati, OH USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2011年 / 107卷 / 08期

关键词：

CARDIOVASCULAR MAGNETIC-RESONANCE; CONGENITAL HEART-DISEASE; FIBROSIS; AGE;

D O I：

10.1016/j.amjcard.2010.12.026

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Left ventricular (LV) systolic dysfunction has been observed in patients with repaired tetralogy of Fallot (TOF), although its clinical associations are unknown. Adults with repaired TOF were identified from 11 adult congenital heart disease centers. Clinical history was reviewed. Patients with pulmonary atresia were excluded. Echocardiograms were reanalyzed to estimate LV ejection fraction. LV function was defined as normal (LV ejection fraction >= 55%) or mildly (45% to 54%), moderately (35% to 44%), or severely (<35%) decreased. Right ventricular (RV) and LV dimensions and Doppler parameters were remeasured. Function of all valves was qualitatively scored. Of 511 patients studied, LV systolic dysfunction was present in 107 (20.9%, 95% confidence interval 17.4 to 24.5). Specifically, 74 (14.4%) had mildly decreased and 33 (6.3%) had moderately to severely decreased systolic function. Presence of moderate to severe LV dysfunction was associated with male gender, LV enlargement, duration of shunt before repair, history of arrhythmia, QRS duration, implanted cardioverter defibrillator, and moderate to severe RV dysfunction. Severity or duration of pulmonary regurgitation was not different. In conclusion, LV systolic dysfunction was found in 21% of adult patients with TOF and was associated with shunt duration, RV dysfunction, and arrhythmia. (C) 2011 Elsevier Inc. All rights reserved. (Am J Cardiol 2011;107:1215-1220)

引用

页码：1215 / 1220

页数：6

共 21 条

[1] Value of the new Doppler-derived myocardial performance index for the evaluation of right and left ventricular function following repair of tetralogy of Fallot [J].