Toll-like receptor 2 is present in the microenvironment of oral squamous cell carcinoma

被引：38
作者：
Ng, L. K. [1 ]
Rich, A. M. [1 ]
Hussaini, H. M. [1 ]
Thomson, W. M. [1 ]
Fisher, A. L. [1 ]
Horne, L. S. [1 ]
Seymour, G. J. [1 ]
机构：
[1] Univ Otago, Fac Dent, Sir John Walsh Res Inst, Immunopathol Grp, Dunedin 9054, New Zealand
来源：
BRITISH JOURNAL OF CANCER | 2011年 / 104卷 / 03期
关键词：
toll-like receptor 2; dysplasia; hyperplasia; oral squamous cell carcinoma; DOUBLE-EDGED-SWORD; CANCER-CELLS; TUMOR; IMMUNITY; TOLL-LIKE-RECEPTOR-2; ACTIVATION; INNATE; SYSTEM; GROWTH; HEAD;
D O I：
10.1038/sj.bjc.6606057
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
BACKGROUND: The aim of this study was to investigate the expression of toll-like receptor 2 (TLR2) on cells associated with oral squamous cell carcinoma, epithelial dysplasia and irritative hyperplasia, using immunohistochemistry. RESULTS: More immune cells expressed TLR2 in carcinoma and dysplasia than in hyperplasia (P<0.001). No hyperplastic samples showed positive TLR2 staining on keratinocytes, whereas keratinocytes in 64% of cases of carcinoma and 74% of cases of dysplasia were TLR2 positive. CONCLUSION: Positive TLR2 expression in the microenvironment suggests activation of immune surveillance against the altered epithelium, whereas TLR2 expression by malignant keratinocytes may be indicative of resistance to apoptosis as a pro-survival mechanism. British Journal of Cancer (2011) 104, 460-463. doi:10.1038/sj.bjc.6606057 www.bjcancer.com Published online 21 December 2010 (C) 2011 Cancer Research UK
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收藏
页码：460 / 463
页数：4
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