N-(diethoxyphosphoryl)-O-benzylhydroxylamine -: a convenient substrate for the synthesis of N-substituted O-benzylhydroxylamines

被引：11

作者：

Blazewska, K ^{[1
]}

Gajda, T ^{[1
]}

机构：

[1] Lodz Tech Univ Politechn, Inst Organ Chem, PL-90924 Lodz, Poland

来源：

TETRAHEDRON | 2003年 / 59卷 / 51期

关键词：

hydroxylamines; N-alkylation; N-(diethoxyphosphoryl)-O-benzylhydroxylamine;

D O I：

10.1016/j.tet.2003.10.056

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Easily available N-(diethoxyphosphoryl)-O-benzylhydroxylamine was shown to be convenient, orthogonally protected substrate for regioselective N-alkylation by means of diverse halides under basic conditions (sodium hydride/tetrabutylammonium bromide). An efficient procedure for dephosphorylation of N-substituted N-(diethoxyphosphoryl)-O-benzylhydroxylamine to provide N-substituted O-benzylhydroxylamines was also established. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：10249 / 10254

页数：6

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