Transcriptional Control of Metastasis by Integrated Stress Response Signaling

被引：7

作者：

Lu, Si ^{[1
,2
]}

Yang, Li-Xian ^{[1
,2
]}

Cao, Zi-Jian ^{[1
,2
]}

Zhao, Jiang-Sha ^{[1
,2
]}

You, Jia ^{[3
]}

Feng, Yu-Xiong ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 1, Zhejiang Prov Key Lab Pancreat Dis, Inst Translat Med,Sch Med, Hangzhou, Peoples R China

[2] Zhejiang Univ, Canc Ctr, Hangzhou, Peoples R China

[3] Westlake Univ, Sch Life Sci, Hangzhou, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2021年 / 11卷

基金：

中国国家自然科学基金;

关键词：

metastasis; transcription; integrated stress response (ISR); cancer; EMT; TUMOR-CELL CLUSTERS; PROTEIN-KINASE PKR; ENDOPLASMIC-RETICULUM; TRANSLATIONAL REGULATION; CANCER METASTASIS; MECHANISMS; SURVIVAL; PATHWAY; PRECURSORS; SUBSTRATE;

D O I：

10.3389/fonc.2021.770843

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

As a central cellular program to sense and transduce stress signals, the integrated stress response (ISR) pathway has been implicated in cancer initiation and progression. Depending on the genetic mutation landscape, cellular context, and differentiation states, there are emerging pieces of evidence showing that blockage of the ISR can selectively and effectively shift the balance of cancer cells toward apoptosis, rendering the ISR a promising target in cancer therapy. Going beyond its pro-survival functions, the ISR can also influence metastasis, especially via proteostasis-independent mechanisms. In particular, ISR can modulate metastasis via transcriptional reprogramming, in the help of essential transcription factors. In this review, we summarized the current understandings of ISR in cancer metastasis from the perspective of transcriptional regulation.

引用

页数：7

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