BISC: Binary SubComplexes in proteins database

被引：4
作者：
Juettemann, Thomas [1 ,2 ]
Gerloff, Dietlind L. [1 ]
机构：
[1] Univ Calif Santa Cruz, Dept Biomol Engn, Santa Cruz, CA 95064 USA
[2] Univ Edinburgh, Sch Biol, Edinburgh EH9 3JJ, Midlothian, Scotland
来源：
NUCLEIC ACIDS RESEARCH | 2011年 / 39卷
关键词：
MULTIPLE SEQUENCE ALIGNMENT; INTERFACES; PDB; RESOURCES; COMPLEXES; DOCKING; UPDATE; IMPACT; DOMAIN; SERVER;
D O I：
10.1093/nar/gkq859
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Binary subcomplexes in proteins database (BISC) is a new protein-protein interaction (PPI) database linking up the two communities most active in their characterization: structural biology and functional genomics researchers. The BISC resource offers users (i) a structural perspective and related information about binary subcomplexes (i.e. physical direct interactions between proteins) that are either structurally characterized or modellable entries in the main functional genomics PPI databases BioGRID, IntAct and HPRD; (ii) selected web services to further investigate the validity of postulated PPI by inspection of their hypothetical modelled interfaces. Among other uses we envision that this resource can help identify possible false positive PPI in current database records. BISC is freely available at http://bisc.cse.ucsc.edu.
引用
收藏
页码：D705 / D711
页数：7
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