Long Non-coding RNAs: Potential Players in Cardiotoxicity Induced by Chemotherapy Drugs

被引：5

作者：

Amrovani, Mehran ^{[1
]}

Mohammadtaghizadeh, Mohammadjavad ^{[2
]}

Aghaali, Mahsa Karimzadeh ^{[3
]}

Zamanifard, Somayeh ^{[4
]}

Alqasi, Arash ^{[5
]}

Sanei, Mozhdeh ^{[6
]}

机构：

[1] High Inst Educ & Res Transfus Med, Tehran, Iran

[2] Ahvaz Jundishapur Univ Med Sci, Atherosclerosis Res Ctr, Ahvaz, Iran

[3] Iran Univ Med Sci, Rajaie Cardiovasc Med & Res Ctr, Tehran, Iran

[4] Univ Tehran Med Sci, Shariati Hosp, Dept Cardiol, Tehran, Iran

[5] Ahvaz Jundishapur Univ Med Sci, Thalassemia & Hemoglobinopathy Res Ctr, Res Inst Hlth, Ahvaz, Iran

[6] Shiraz Univ Med Sci, Fac Med, Student Res Comm, Shiraz, Iran

来源：

CARDIOVASCULAR TOXICOLOGY | 2022年 / 22卷 / 03期

关键词：

Long non-coding RNAs; Cardiotoxicity; Cardiomyocyte; Mechanism; SMOOTH-MUSCLE-CELL; ENHANCES CISPLATIN SENSITIVITY; BLADDER-CANCER CELLS; PROMOTES PROLIFERATION; GASTRIC-CANCER; WNT/BETA-CATENIN; BREAST-CANCER; INHIBITS APOPTOSIS; PROSTATE-CANCER; CARDIOMYOCYTE APOPTOSIS;

D O I：

10.1007/s12012-021-09681-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

One of the most important side effects of chemotherapy is cardiovascular complications, such as cardiotoxicity. Many factors are involved in the pathogenesis of cardiotoxicity; one of the most important of which is long non-coding RNAs (lncRNAs). lncRNA has 200-1000 nucleotides. It is involved in important processes such as cell proliferation, regeneration and apoptosis; today it is used as a prognostic and diagnostic factor. A, various drugs by acting on lncRNAs can affect cells. Therefore, by accurately identifying IncRNAs function, we can play an effective role in preventing the development of cardiotoxicity-induced chemotherapy drugs, and use them as a therapeutic strategy to improve clinical symptoms and increase patient survival.

引用

页码：191 / 206

页数：16

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