CDK7 inhibition suppresses AR addicted Castration-Resistant Prostate Cancer through MED1 inactivation

被引：0
|
作者：
Rasool, Reyaz [1 ]
Natesan, Ramakrishnan [1 ]
Qu Deng [1 ]
Aras, Shweta [1 ]
Lal, Priti [1 ]
Posimo, Jessica [1 ]
Palanisamy, Nallasivam [2 ]
Narla, Goutham [3 ]
Den, Robert [4 ]
Freedman, Matthew [5 ]
Brady, Donita [1 ]
Asangani, Irfan A. [1 ]
机构：
[1] Univ Penn, Philadelphia, PA 19104 USA
[2] Vattikuti Urol Inst, Detroit, MI USA
[3] Univ Michigan, Ann Arbor, MI 48109 USA
[4] Thomas Jefferson, Philadelphia, PA USA
[5] Harvard Med Sch, Boston, MA 02115 USA
来源：
MOLECULAR CANCER THERAPEUTICS | 2019年 / 18卷 / 12期
关键词：
D O I：
10.1158/1535-7163.TARG-19-B016
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
B016
引用
收藏
页数：2
相关论文
共 50 条
  • [1] CDK7 Inhibition Suppresses Castration-Resistant Prostate Cancer through MED1 Inactivation
    Rasool, Reyaz Ur
    Natesan, Ramakrishnan
    Deng, Qu
    Aras, Shweta
    Lal, Priti
    Effron, Samuel Sander
    Mitchell-Velasquez, Erick
    Posimo, Jessica
    Carskadon, Shannon
    Baca, Sylvan C.
    Pomerantz, Mark M.
    Siddiqui, Javed
    Schwartz, Lauren E.
    Lee, Daniel J.
    Palanisamy, Nallasivam
    Narla, Goutham
    Den, Robert B.
    Freedman, Matthew L.
    Brady, Donita C.
    Asangani, Irfan A.
    CANCER DISCOVERY, 2019, 9 (11) : 1538 - 1555
  • [2] Androgen Receptor Interaction with Mediator Complex Is Enhanced in Castration-Resistant Prostate Cancer by CDK7 Phosphorylation of MED1
    Russo, Joshua W.
    Nouri, Mannan
    Balk, Steven P.
    CANCER DISCOVERY, 2019, 9 (11) : 1490 - 1492
  • [3] Castration-resistant prostate cancer cells are dependent on the high activity of CDK7
    Satu Pallasaho
    Aishwarya Gondane
    Anni Kuivalainen
    Samuel Girmay
    Siver Moestue
    Massimo Loda
    Harri M. Itkonen
    Journal of Cancer Research and Clinical Oncology, 2023, 149 : 5255 - 5263
  • [4] Castration-resistant prostate cancer cells are dependent on the high activity of CDK7
    Pallasaho, Satu
    Gondane, Aishwarya
    Kuivalainen, Anni
    Girmay, Samuel
    Moestue, Siver
    Loda, Massimo
    Itkonen, Harri M.
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2023, 149 (08) : 5255 - 5263
  • [5] ZBTB7A suppresses castration-resistant prostate cancer
    Mina Razzak
    Nature Reviews Clinical Oncology, 2013, 10 (8) : 427 - 427
  • [6] Menin inhibition suppresses castration-resistant prostate cancer and enhances chemosensitivity
    Chaïma Cherif
    Dang Tan Nguyen
    Clément Paris
    Thi Khanh Le
    Thibaud Sefiane
    Nadine Carbuccia
    Pascal Finetti
    Max Chaffanet
    Abdessamad El kaoutari
    Julien Vernerey
    Ladan Fazli
    Martin Gleave
    Mohamed Manai
    Philippe Barthélémy
    Daniel Birnbaum
    François Bertucci
    David Taïeb
    Palma Rocchi
    Oncogene, 2022, 41 : 125 - 137
  • [7] Menin inhibition suppresses castration-resistant prostate cancer and enhances chemosensitivity
    Cherif, Chaima
    Nguyen, Dang Tan
    Paris, Clement
    Le, Thi Khanh
    Sefiane, Thibaud
    Carbuccia, Nadine
    Finetti, Pascal
    Chaffanet, Max
    El Kaoutari, Abdessamad
    Vernerey, Julien
    Fazli, Ladan
    Gleave, Martin
    Manai, Mohamed
    Barthelemy, Philippe
    Birnbaum, Daniel
    Bertucci, Francois
    Taieb, David
    Rocchi, Palma
    ONCOGENE, 2022, 41 (01) : 125 - 137
  • [8] INHIBITION OF p300/CBP SUPPRESSES CASTRATION-RESISTANT PROSTATE CANCER
    Lasko, L. M.
    Jakob, C. G.
    Edalji, R. P.
    Qiu, W.
    Montgomery, D.
    Digiammarino, E. L.
    CANCER DISCOVERY, 2017, 7 (11) : 1215 - 1215
  • [9] Phospho-MED1 mediates the transcriptional regulation of AR splice variants in castration-resistant prostate cancer
    Liu, Gang
    Sprenger, Cynthia
    Wu, Pin-Jou
    Sun, Shihua
    Uo, Takuma
    Haugk, Kathleen
    Epilepsia, Kathryn Soriano
    Plymate, Stephen
    CANCER RESEARCH, 2014, 74 (19)
  • [10] PARP inhibition in castration-resistant prostate cancer
    Nappi, Lucia
    Gleave, Martin E.
    FUTURE ONCOLOGY, 2016, 12 (05) : 577 - 580
12345