The lipid type affects the in vitro digestibility and β-carotene bioaccessibility of liquid or solid lipid nanoparticles

被引：58

作者：

de Abreu-Martins, Heloisa Helena ^{[2
]}

Artiga-Artigas, Maria ^{[1
]}

Piccoli, Roberta Hilsdorf ^{[2
]}

Martin-Belloso, Olga ^{[1
]}

Salvia-Trujillo, Laura ^{[1
]}

机构：

[1] Univ Lleida, Agrotecnio Ctr, Dept Food Technol, Av Alcalde Rovira Roure 191, Lleida 25198, Spain

[2] Univ Fed Lavras, Dept Food Sci, Av Dr Sylvio Menicucci 1001, BR-37200000 Lavras, Brazil

来源：

FOOD CHEMISTRY | 2020年 / 311卷

关键词：

Solid lipid nanoparticles; Oil type; beta-Carotene; Lipid digestibility; Bioaccessibility;

D O I：

10.1016/j.foodchem.2019.126024

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Solid lipid nanoparticles (SLNs) are emulsion-based carriers of lipophilic bioactive compounds. However, their digestibility may be affected by the solid lipid phase composition. Hence, the aim of this work was to study the in vitro lipolysis kinetics as well as the relationship between the lipid digestion, micelle fraction composition and beta-carotene bioaccessibility of SLNs with different solid lipids, being blends of medium chain triglyceride (MCT) oil, glyceryl stearate (GS) or hydrogenated palm oil (HPO) as compared to liquid lipid nanoparticles (LLNs) with pure MCT. SLNs formulated with GS were fully digested, similarly to LLNs. However, HPO-containing SLNs presented slower lipolysis kinetics during the intestinal phase at increasing HPO concentration. Despite this, HPO-SLNs showed higher beta-carotene bioaccessibility, which was related to the higher amount of monounstaturated free fatty acids in the micelle fraction. Thus, this work provides valuable insight for designing delivery systems of bioactive compounds with optimal functionality.

引用

页数：10

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