Gold(III)-catalyzed synthesis of 2,5-disubstituted furans from substituted 5-methoxyhex-3-yn-2-ols-Mechanistic outlook

被引：1

作者：

Behera, Sagarika ^{[1
]}

Bera, Nabakumar ^{[1
]}

Sarkar, Debayan ^{[1
]}

机构：

[1] Natl Inst Technol, Organ Synth & Mol Engn Lab, Rourkela 769008, India

来源：

SYNTHETIC COMMUNICATIONS | 2021年 / 51卷 / 20期

关键词：

Allenyl carbocation; 5-endo-dig; one-pot; open-air; propargyl ether; GOLD CATALYSIS; DERIVATIVES; TRANSFORMATION; ACTIVATION; THIOPHENE; SUGARS;

D O I：

10.1080/00397911.2021.1961274

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Gold(III)-catalyzed activation of alkynes has been applied for the synthesis of 2,5-disubstituted furans from substituted 5-methoxy-hex-3-yn-2-ols. Mechanistically, the reaction proceeds via an allenyl carbocation intermediate followed by 5-endo-dig cyclization. The high-yielding, open-air, room temperature reaction conditions applied to synthesize a series of alkyl, aryl, and hetero aryl-substituted furans provide uniqueness to the strategy.

引用

页码：3090 / 3098

页数：9