Amygdala Circuits for Fear Memory: A Key Role for Dopamine Regulation

被引：43
作者：
Lee, Joo Han [1 ]
Lee, Seungho [1 ]
Kim, Joung-Hun [1 ]
机构：
[1] Pohang Univ Sci & Technol POSTECH, Dept Life Sci, 77 Cheongam Ro, Pohang 37673, Gyeongbuk, South Korea
来源：
NEUROSCIENTIST | 2017年 / 23卷 / 05期
基金：
新加坡国家研究基金会;
关键词：
dopamine; amygdala; neural circuits; synaptic plasticity; posttraumatic stress disorder (PTSD); VENTRAL TEGMENTAL AREA; CORTICOTROPIN-RELEASING-FACTOR; POSTTRAUMATIC-STRESS-DISORDER; RAT BASOLATERAL AMYGDALA; RECEPTOR MESSENGER-RNA; CONDITIONED FEAR; PARVALBUMIN INTERNEURONS; GABAERGIC TRANSMISSION; INTERCALATED NEURONS; INHIBITORY CIRCUITS;
D O I：
10.1177/1073858416679936
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
In addition to modulating a number of cognitive functions including reward, punishment, motivation, and salience, dopamine (DA) plays a pivotal role in regulating threat-related emotional memory. Changes in neural circuits of the amygdala nuclei are also critically involved in the acquisition and expression of emotional memory. In this review, we summarize the regulation of amygdala circuits by DA. Specifically, we describe DA signaling in the amygdala, and DA regulation of synaptic transmission and synaptic plasticity of the amygdala neurons. Finally, we discuss a potential contribution of DA-related mechanisms to the pathogenesis of posttraumatic stress disorder.
引用
收藏
页码：542 / 553
页数：12
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